|Application ||IHC, E|
|Other Accession||NP_060173.1, 54850, 30843 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||37026 Da|
|Other Names||F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL12 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.|
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Provided below are standard protocols that you may find useful for product applications.
A family of mammalian F-box proteins. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW. Curr Biol. 1999 Oct 21;9(20):1180-2. PMID: 10531037
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