|Application ||IHC, E|
|Other Accession||NP_004811.1, 9420|
|Calculated MW||58256 Da|
|Other Names||25-hydroxycholesterol 7-alpha-hydroxylase, 220.127.116.11, Cytochrome P450 7B1, Oxysterol 7-alpha-hydroxylase, CYP7B1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP7B1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol (PubMed:10588945). Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. Wu Z, Martin KO, Javitt NB, Chiang JY. J Lipid Res. 1999 Dec;40(12):2195-203. PMID: 10588945
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