|Other Accession||NP_055461.1, 9663|
|Predicted||Human, Mouse, Rat, Pig|
|Calculated MW||99399 Da|
|Other Names||Phosphatidate phosphatase LPIN2, 18.104.22.168, Lipin-2, LPIN2, KIAA0249|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Lipin 2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate.|
|Tissue Location||Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. Phan J, Peterfy M, Reue K. J Biol Chem. 2004 Jul 9;279(28):29558-64. Epub 2004 Apr 29. PMID: 15123608
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