|Application ||WB, E|
|Other Accession||NP_000036.2, 383, 11846 (mouse), 29221 (rat)|
|Reactivity||Human, Mouse, Rat, Pig|
|Calculated MW||34735 Da|
|Other Names||Arginase-1, 188.8.131.52, Liver-type arginase, Type I arginase, ARG1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Arginase I Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.|
|Cellular Location||Cytoplasm. Cytoplasmic granule. Note=Localized in azurophil granules of neutrophils (PubMed:15546957)|
|Tissue Location||Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409).|
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