|Application ||WB, E|
|Other Accession||NP_775259.1, NP_001028748.1, 146862, 217012 (mouse), 303373 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||103733 Da|
|Other Names||Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC45B Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.|
|Cellular Location||Cytoplasm, cytosol.|
|Tissue Location||Expressed in eye lens tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_775259.1and NP_001028748.1).
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. Landsverk ML, Li S, Hutagalung AH, Najafov A, Hoppe T, Barral JM, Epstein HF. J Cell Biol. 2007 Apr 23;177(2):205-10. Epub 2007 Apr 16. PMID: 17438072
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