|Other Accession||NP_150296.3, 10595|
|Calculated MW||102480 Da|
|Other Names||Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, 220.127.116.11, Endoribonuclease, 3.1.26.-, ERN2 (HGNC:16942)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERN2 / IRE1b Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
PERK mediates cell-cycle exit during the mammalian unfolded protein response. Brewer JW, Diehl JA. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12625-30. PMID: 11035797
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.