|Other Accession||NP_003950.1, 9026|
|Predicted||Human, Pig, Dog, Cow|
|Calculated MW||119388 Da|
|Other Names||Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R, HIP12, KIAA0655|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIP1R/ HIP12 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.|
|Cellular Location||Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region|
|Tissue Location||Brain, heart, kidney, pancreas, and liver, but not in lung or placenta|
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Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly. Poupon V, Girard M, Legendre-Guillemin V, Thomas S, Bourbonniere L, Philie J, Bright NA, McPherson PS, Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 105 (1): 168-73. PMID: 18165318
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