|Application ||WB, E|
|Other Accession||NP_001124.1, 173, 75547 (mouse), 293024 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||69069 Da|
|Other Names||Afamin, Alpha-albumin, Alpha-Alb, AFM, ALB2, ALBA|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Afamin / alpha Albumin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:15952736, PubMed:12463752). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407).|
|Tissue Location||High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier. Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W. Journal of neurochemistry 2009 Feb 108 (3): 707-18. PMID: 19046407
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