|Application ||WB, E|
|Other Accession||NP_002816.1, 5764, 19242 (mouse), 24924 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||18942 Da|
|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Pleiotrophin / PTN Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant Kretschmer PJ, Fairhurst JL, Hulmes JD, Popjes ML, Böhlen P, Kovesdi I Biochem Biophys Res Commun. 1993 Apr 30;192(2):420-9. PMID: 8484754
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