|Application ||WB, E|
|Other Accession||NP_036458.2, 22924, 100732 (mouse)|
|Calculated MW||31982 Da|
|Other Names||Microtubule-associated protein RP/EB family member 3, EB1 protein family member 3, EBF3, End-binding protein 3, EB3, RP3, MAPRE3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAPRE3 (aa151-164) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules|
|Tissue Location||Predominantly expressed in brain and muscle.|
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Mammalian end binding proteins control persistent microtubule growth. Komarova Y, De Groot CO, Grigoriev I, Gouveia SM, Munteanu EL, Schober JM, Honnappa S, Buey RM, Hoogenraad CC, Dogterom M, Borisy GG, Steinmetz MO, Akhmanova A, The Journal of cell biology 2009 Mar 184 (5): 691-706. PMID: 19255245
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