|Application ||WB, E|
|Other Accession||NP_116244.1, 84941, 209488 (mouse)|
|Calculated MW||39002 Da|
|Other Names||Hematopoietic SH2 domain-containing protein, Hematopoietic SH2 protein, Adaptor in lymphocytes of unknown function X, HSH2D, ALX|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSH2D Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation. Shapiro MJ, Chen YY, Shapiro VS, The Journal of biological chemistry 2005 Nov 280 (46): 38242-6. PMID: 16169852
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