|Application ||WB, E|
|Other Accession||NP_001245.1, 990|
|Calculated MW||62720 Da|
|Other Names||Cell division control protein 6 homolog, CDC6-related protein, Cdc18-related protein, HsCdc18, p62(cdc6), HsCDC6, CDC6, CDC18L|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDC6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|
|Cellular Location||Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895)|
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Provided below are standard protocols that you may find useful for product applications.
ATR (AT mutated Rad3 related) activity stabilizes Cdc6 and delays G2/M-phase entry during hydroxyurea-induced S-phase arrest of HeLa cells. Liu L, Choi JH, Yim H, Choi JS, Park BD, Cho SJ, Lee SK, The international journal of biochemistry & cell biology 2009 Jun 41 (6): 1410-20. PMID: 19154794
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