|Application ||WB, E|
|Other Accession||NP_001108108.1, NP_060532.2, 55120, 67030 (mouse), 305600 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||42905 Da|
|Other Names||E3 ubiquitin-protein ligase FANCL, 6.3.2.-, Fanconi anemia group L protein, Fanconi anemia-associated polypeptide of 43 kDa, FAAP43, FANCL, PHF9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FANCL Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both isoforms (NP_001108108.1; NP_060532.2).
Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition. García MJ, Fernández V, Osorio A, Barroso A, Fernández F, Urioste M, Benítez J. Carcinogenesis 2009 Nov 30 (11): 1898-902. PMID: 19737859
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