|Application ||WB, E|
|Other Accession||NP_004565.1, NP_536341.1, NP_001185642.1, 5414, 18952 (mouse)|
|Calculated MW||55098 Da|
|Other Names||Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT4 (aa425-435) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARTS, PNUTL2, SEP4|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=In platelets, found in areas surrounding alpha-granules. Found in the sperm annulus (PubMed:25588830).|
|Tissue Location||Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung Also expressed in colorectal cancers and malignant melanomas Expressed in platelets.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 (NP_004565.1), 3 (NP_536341.1) and 4 (NP_001185642.1). Amino acid numbering in name refers to NP_004565.1 sequence.
Absence of annulus in human asthenozoospermia: case report. Lhuillier P, Rode B, Escalier D, Lorès P, Dirami T, Bienvenu T, Gacon G, Dulioust E, Touré A Human reproduction (Oxford, England) 2009 Jun 24 (6): 1296-303. PMID: 19221096
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