|Application ||WB, E|
|Other Accession||NP_945327.1, 51497, 57314 (mouse)|
|Predicted||Mouse, Pig, Dog, Cow|
|Calculated MW||66247 Da|
|Other Names||Negative elongation factor C/D, NELF-C/D, TH1-like protein, NELFCD, NELFD, TH1, TH1L|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TH1L Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NELFD, TH1, TH1L|
|Function||Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401).|
|Tissue Location||Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.|
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Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation. Yang Y, Zou W, Kong X, Wang H, Zong H, Jiang J, Wang Y, Hong Y, Chi Y, Xie J, Gu J, Journal of cellular biochemistry 2010 Apr 109 (5): 1013-24. PMID: 20069563
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