|Application ||WB, E|
|Other Accession||NP_000407.1, 3459|
|Calculated MW||54405 Da|
|Other Names||Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, CD119, IFNGR1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFNGR1 (aa181-193) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. Slattery ML, Lundgreen A, Bondurant KL, Wolff RK. Carcinogenesis. 2011 Nov;32(11):1660-7. PMID: 21859832
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