|Application ||WB, E|
|Other Accession||NP_001941.2, 1874, 104394 (mouse), 100360427 (rat)|
|Predicted||Mouse, Pig, Dog, Cow|
|Calculated MW||43960 Da|
|Other Names||Transcription factor E2F4, E2F-4, E2F4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Transcription factor E2F4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.|
|Tissue Location||Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG, Benevolenskaya EV. Proceedings of the National Academy of Sciences of the United States of America 2012 Nov 109 (45): 18499-504. PMID: 23093672
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