|Application ||WB, E|
|Other Accession||NP_000704.1, 645|
|Calculated MW||22119 Da|
|Other Names||Flavin reductase (NADPH), FR, 18.104.22.168, Biliverdin reductase B, BVR-B, 22.214.171.124, Biliverdin-IX beta-reductase, Green heme-binding protein, GHBP, NADPH-dependent diaphorase, NADPH-flavin reductase, FLR, BLVRB, FLR|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BLVRB (aa38-49) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.|
|Tissue Location||Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.|
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Provided below are standard protocols that you may find useful for product applications.
Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase. Smith LJ, Browne S, Mulholland AJ, Mantle TJ. The Biochemical journal 2008 May 411 (3): 475-84. PMID: 18241201
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