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>   home   >   Products   >   Primary Antibodies   >   Zinc-Activated Channel (ZAC) (extracellular) Antibody   

Zinc-Activated Channel (ZAC) (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Zinc-Activated Channel (ZAC) (extracellular) Antibody AG1001-050
    Western blot analysis of Panc-1 (lanes 1 and 3) and Jurkat (lanes 2 and 4) cell lysates: 1, 2. Anti-Zinc-Activated Channel (ZAC) (extracellular) antibody (#AG1001), (1:200).
    3, 4. Anti-Zinc-Activated Channel (ZAC) (extracellular) antibody, preincubated with the control peptide antigen.
  • ICC - Zinc-Activated Channel (ZAC) (extracellular) Antibody AG1001-050
    Expression of Zinc-Activated Channel (ZAC) in human (PANC-1) cells Immunocytochemical staining of human intact living epitheioid carcinoma (PANC-1) cells. Extracellular staining (green) of cells with Anti-Zinc-Activated Channel (ZAC) (extracellular) antibody (#AG1001), (1:25) followed by goat anti-rabbit-AlexaFluor-488 secondary antibody. DAPI is used as the counterstain (blue).
  • FC - Zinc-Activated Channel (ZAC) (extracellular) Antibody AG1001-050
    Indirect flow cytometry analysis of Jurkat living cells: ___ Unstained cells.
    ___ Cells + Anti-Zinc-Activated Channel (ZAC) (extracellular) antibody (#AG1001), (5-10 µg/1x106 cells).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q401N2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45816 Da
Homology Human.
Additional Information
Gene ID 353174
Other Names Zinc-activated ligand-gated ion channel, Ligand-gated ion channel zinc-activated 1, Ligand-gated ion-channel receptor L2, ZACN, L2, LGICZ, LGICZ1, ZAC
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CNFELLHFPRDHSN, corresponding to amino acid residues 157-170 of human zinc-activated channel (ZAC) (Accession Q401N2).ֲ ֲ Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Over forty homologous proteins belong to the superfamily of ligand-gated ion channels. These members are broken down into different subfamilies, for example: acetylcholine, serotonin and glycine receptors. A new member has been added to this superfamily – ZAC (zinc-activated channel) which is expressed in human and dog but not in rodents1. Like all other ligand-gated ion channels, ZAC has four transmembrane domains and extracellular N- and C-termini. As its name states, the channel is activated by high concentrations of zinc. ZAC mRNA was found to be expressed in placenta, spinal cord, stomach, and fetal brain1. In another study, ZAC was identified using a computer-assisted program and was detected in similar areas (including pancreas and kidney), but also displayed minor discrepancies2. Being that the channel is expressed in human and dog, deciphering its cellular/physiological functions will be challenging.


References 1. Davies, P.A. et al. (2003) J. Biol. Chem. 278, 712. 2. Houtani, T. et al. (2005) Biochem. Biophys. Res. Comm. 335, 277.

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$ 367.00
$ 475.00
Cat# AG1001-050
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