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ENaCgamma Antibody

Affinity purified polyclonal antibody

  • WB - ENaCgamma Antibody AG1033-050
    Western blot analysis of rat lung lysate: 1. Anti-ENaCγ antibody (#AG1033), (1:200).
    2. Anti-ENaCγ antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P37091
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 74066 Da
Homology Human - 13/17 amino acid residues identical.
Additional Information
Gene ID 24768
Other Names Amiloride-sensitive sodium channel subunit gamma, Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG, Scnn1g
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)YGVKESRKRREAGS, corresponding to amino acid residues 129-142 of rat ENaC־³ֲ (Accession P37091). Extracellular.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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The amiloride-sensitive epithelial Na+ channel (ENaCs) family includes 4 members: ENaCα, β, γ and δ. The ENaC channel is located in the luminal (apical) plasma membrane of  several epithelial tissues such as kidney, lung, salivary glands and skin.   The functional channel is believed to be a multimer including a α (or δ) and a β and γ subunits  with a likely stoichiometry of α2βγ. ENaC channel enable entry of Na+ into the cell  along its electrochemical gradient and thus has a central role in the maintenance of  renal Na+ balance (and hence blood pressure) and liquid balance in the lung. Indeed, genetic mutations in the ENaC subunits causes Liddle’s syndrome (a form of hypertension) or pseudohypoaldosteronism type 1 (PHA) that is characterized by hypotension.  The ENaC channel is voltage-independent and is constitutively active in epithelia although  it is modulated by several different mechanisms. One of the main mechanisms is the controlled internalization of the channel that is dependent  on the β or γ subunits. Indeed, mutations in the C-termini of these subunits reduce endocytosis  of the channel leading to the accumulation of ENaC in the cell membrane and causing a phenotype that is consistent with that of Liddle’s syndrome. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat ENaCγ. The Anti-ENaCγ antibody (#AG1033) can be used in western blot analysis. It has been designed to recognize ENaCγ from rat and human samples.


References 1. Kellenberger, S. et al. (2003) J. Biol.Chem. 278, 29153.  2. Snyder, P.M. (2002) Endocrine Rev. 23, 258. 

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$ 367.00
$ 475.00
Cat# AG1033-050
Availability: 2-3 weeks
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