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P2Y11 Receptor Antibody

Affinity purified rabbit polyclonal antibody

  • WB - P2Y11 Receptor Antibody AG1066-025
    Western blot analysis human platelet lysates: 1. Anti-P2Y11 Receptor antibody (#AG1066), (1:200). 2. Anti-P2Y11 Receptor antibody, preincubated with the control peptide antigen.
  • IHC - P2Y11 Receptor Antibody AG1066-025
    Expression of P2Y11 receptor in rat spleen Immunohistochemical staining of rat spleen using Anti-P2Y11 Receptor antibody (#AG1066). Secondary (activated) follicle in the spleen white pulp shows intense staining of Marginal Zone T lymphocytes (red arrow); note that cells in the red pulp (green arrow) and B lymphocytes in the germinal center (blue arrow) are not stained. Yellow arrows show mononuclear cells with intense stain, probably non specific due to very high intrinsic peroxidase activity. DAB product is brown and cresyl violet is used as the counterstain. The two images are the same at different augmentation (Left pane 200x and right pane 400x).
  • ICC - P2Y11 Receptor Antibody AG1066-025
    Expression of P2Y11 receptor in human P2Y11-MDCK transfected cells Immunocytochemical staining of paraformaldehyde-fixed and permeabilized human P2Y11-MDCK transfected cells. A. Staining using Anti-P2Y11 Receptor antibody (#AG1066), (1:200), followed by Alexa-488-conjugated goat-anti-rabbit secondary antibody. B. Nuclear fluorescence staining of cells using the membrane-permeable DNA dye Hoechst 33342. C. Merged images of panels A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96G91
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 40345 Da
Homology Rat, mouse - 16/18 amino acid residues identical.
Additional Information
Gene ID 5032
Other Names P2Y purinoceptor 11, P2Y11, P2RY11
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)NATAAPKPSEPQSRELS, corresponding to amino acid residues 357-373 of human P2Y11 (Accession Q96G91). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Application Details Western blot analysis (WB): - Human derived keratinocytes (HaCaT cells), (1:200), (see Ishimaru, M. et al. (2013) in Product Citations). Indirect flow cytometry (IFC): - Rat osteoclasts (6 μg/ml) (see Alvarenga, E.C. et al. (2010) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.9 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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The P2Y receptors belong to the G-protein coupled receptors superfamily. They mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP). Eight functional mammalian P2Y receptors have been described: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.1-3 The human P2Y11 receptor is unique among the P2Y receptors since it is dually coupled to phospholipase C and adenylyl cyclase.4-5 P2Y11 receptor is highly pressed in spleen and for much lower extent at platelets. Expression of P2Y11 receptor was also shown in endothelial cells.6 In granulocytes HL-60), P2Y11 receptor is thought to have a role in granulocytic differentiation.4,7


1. Queiroz, G. et al. (2003) J. Pharmacol. Exp. Ther. 307, 809.
2. Ralevic, V. and Burnstock, G. (1998) Pharmacol. Rev. 50, 413.
3. Abbracchio, M.P. et al. (2003) Trends. Pharmacol. Sci. 24, 52.
4. Communi, D. et al. (2000) FEBS Letters 475, 39.
5. White, P.J. et al. (2003) Mol. Pharmacol. 63, 1356.
6. Wang, L. et al. (2002) J. Cardiovas. Pharmacol. 40, 841.

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$ 247.00
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$ 475.00
Cat# AG1066-025
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