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Neuropeptide Y1 Receptor Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Neuropeptide Y1 Receptor Antibody AG1189-050
    Western blot analysis of Jurkat (lanes 1 and 4), K562 (lanes 2 and 5), and RBL (lanes 3 and 6) cell lysates and rat brain lysates (lanes 7 and 8): 1, 2, 3, 7. Anti-Neuropeptide Y1 Receptor antibody (#AG1189), (1:200). 4, 5, 6, 8. Anti-Neuropeptide Y1 Receptor antibody preincubated with the control peptide antigen.
  • IHC - Neuropeptide Y1 Receptor Antibody AG1189-050
    Expression of NPY1R in rat striatum Immunohistochemical staining of rat striatum using Anti-Neuropeptide Y1 Receptor antibody (#AG1189). A. NPY1R (red) appears in the striatal matrix (white asterik) and in medium-size cells in the matrix (arrows). B. Parvalbumin (green) appears in the striatal matrix. C. confocal merge of NPY1R and parvalbumin indicates that NPY1R is restricted to granule cells. DAPI is used as the counterstain (blue).
  • ICC - Neuropeptide Y1 Receptor Antibody AG1189-050
    Expression of NPY1R in DRG neurons Immunocytochemical staining of a primary culture of rat dorsal root ganglion (DRG) neurons. A, D. A paraformaldehyde-fixed and permeabilized DRG primary culture was stained with Anti-Neuropeptide Y1 Receptor antibody (#AG1189), (1:100), followed by Alexa-555-conjugated goat-anti-rabbit secondary antibody. B, E. Nuclear fluorescence staining of cells using the membrane-permeable DNA dye Hoechst 33342. C. Merged images of A and B. F. Merged images of D and E. Magnification: A-C: x20 E-F: x100
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25929
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 44392 Da
Homology Rat, mouse - 14/16 amino acid residues identical.
Additional Information
Gene ID 4886
Other Names Neuropeptide Y receptor type 1, NPY1-R, NPY1R, NPYR, NPYY1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)RLKRRNNMMDKMRDNK, corresponding to amino acid residues 237-252 of human NPY1R (Accession P25929). 3rd intracellular loop.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.75 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with the peptide YY (PYY) and the pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2 NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R) and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2 The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus. Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2 NPY1R is considered to be a postsynaptic receptor. In the CNS, NPY1Rs are concentrated in the cortical areas of the brain, cerebral cortex, olfactory nucleus, hippocampus, hypothalamic nuclei, and thalamic nuclei.4 In addition, this receptor has a bimodal role in the immune system, serving as a strong negative regulator on T cells as well as a key activator of antigen-presenting cell function.5 Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of the human neuopeptide Y1 receptor (NPY1R). The Anti-Neuropeptide Y1 Receptor antibody (#AG1189) can be used for western blot analysis and immunocytochemical staining applications, and should recognize NPY1R from human, rat, and mouse samples.


1. Stanic, D. et al. (2006) J. Comp. Neurol. 499, 357.
2. Körner, M. et al. (2004) Clin. Can. Res. 10, 8426.
3. Sun, L. and Miller, R.J. (1999) J. Neurophysiol. 81, 1391.
4. Bournat, J.C. and Allen, J.M. (2001) Brain Res. Mol. Brain Res. 90, 149.
5. Wheway, J. et al. (2005) J. Exp. Med. 202, 1527.

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$ 367.00
$ 475.00
Cat# AG1189-050
Availability: 2-3 weeks
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