Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone ALPP/516 ]
|Application ||IHC-F, IF, FC|
|Other Accession||250, 284255|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Alkaline phosphatase, placental type, 22.214.171.124, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Detected in placenta (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
PLAP is a tissue specific, trophoblast-derived, 70kDa, glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+ metallo-glycoprotein that catalyzes the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. It is present in the placenta and serum of pregnant women and in high frequency in gynecological and testicular cancers and in lower frequency in other tumors. The three tissue-specific APā€™s in humans, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous. Non-tissue specific AP is found in kidney, liver and bone. This MAb binds equally well to all common allelic variants (S, F, FS and I) of PLAP and to some variants of AP from normal human testis. This MAb can be used as tracer antibody in ELISA to detect PLAP in serum of S, F, FS and I phenotypes.
Millan J.L. et. al., Antigenic determinants of human placental and testicular alkaline phosphatase as mapped by monoclonal antibodies. Eur. J. Biochem. 136: 1-12, (1983). | Riklund K.E. et. al., Experimental radio-immunotherapy of HeLa tumors in nude mice with 131I-labeled monoclonal antibodies. Anticancer Research, 1990, 10:379-84
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.