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Mouse Monoclonal Antibody [Clone FR4A5 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC |
|---|---|
| Primary Accession | P22083 |
| Other Accession | 2526, 654379 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM, kappa |
| Clone Names | FR4A5 |
| Calculated MW | ~220kDa (Glycoprotein) |
| Gene ID | 2526 |
|---|---|
| Other Names | Alpha-(1, 3)-fucosyltransferase 4, 2.4.1.-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUT4 |
|---|---|
| Synonyms | ELFT, FCT3A |
| Function | May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD15 plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. In addition, CD15 is expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin’s disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.
References
Bettelheim, P., et al., Cluster Report: CD15, in : Knapp, W., et al. (eds), Leucocyte Typing IV, Oxford Univ. Press, pp 798-799. | Hogg, N., et al., Myeloid antigens: new and previously defines clusters, in: McMichae, A.J., et al (eds), Leucocyte Typing III, Oxford Univ. Press, pp 576-602
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