GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Antibody - With BSA and Azide
Rat Monoclonal Antibody [Clone SPM249 ]
|Application ||WB, IHC-P, IF, FC|
|Other Accession||7184, 192374|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Cow, Sheep, Xenopus, Horse, Guinea Pig, Dog|
|Isotype||Rat / IgG2a, kappa|
|Other Names||Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||GRP94 / HSP90B1 (Endoplasmic Reticulum Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.|
|Cellular Location||Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96). Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90). This MAb is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp s are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.
Sorger, P.K. et al. J. Mol. Biol. 194: 341-344 (1987). | Tandon, A.K. et.al. Breast Cancer Res. and Treat. 16: 146 (1990). |
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.