CD5 (Mantle Cell Lymphoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone B-B8 ]
|Application ||IF, FC|
|Other Accession||921, 58685|
|Isotype||Mouse / IgG1, kappa|
|Other Names||T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5, CD5, LEU1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD5 (Mantle Cell Lymphoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a receptor in regulating T-cell proliferation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Recognizes a 67kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.
Berezowski K; et al. American Journal of Clinical Pathology, 1996 Oct, 106(4):483-6. | Ferry JA; et al. American Journal of Clinical Pathology, 1996 Jan, 105(1):31-7
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