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MNT Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - MNT Antibody - C-terminal region AI10070
    MNT Antibody (AI10070) in Human Fetal Lung using Western Blot
    Host: Rabbit
    Target Name: MNT
    Sample Tissue: Fetal Lung lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q99583
Other Accession Q99583, NP_064706
Reactivity Human
Predicted Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 64 kDa
Additional Information
Alias Symbol MNT, BHLHD3, ROX,
Other Names Max-binding protein MNT, Class D basic helix-loop-helix protein 3, bHLHd3, Myc antagonist MNT, Protein ROX, MNT, BHLHD3, ROX
Target/Specificity The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul, l of distilled water. Final Anti-MNT antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMNT Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MNT
Synonyms BHLHD3, ROX
Function Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Cellular Location Nucleus. EMBL; X96401; CAA65265.1; -; mRNA EMBL; Y13440; CAA73851.1; -; Genomic_DNA EMBL; Y13441; CAA73851.1; JOINED; Genomic_DNA EMBL; Y13442; CAA73851.1; JOINED; Genomic_DNA EMBL; Y13443; CAA73851.1; JOINED; Genomic_DNA EMBL; Y13444; CAA73851.1; JOINED; Genomic_DNA EMBL; AK291596; BAF84285.1; -; mRNA EMBL; CH471108; EAW90541.1; -; Genomic_DNA EMBL; CH471108; EAW90542.1; -; Genomic_DNA EMBL; BC117563; AAI17564.1; -; mRNA CCDS; CCDS11018.1; - RefSeq; NP_064706.1; NM_020310.2 UniGene; Hs.626579; - UniGene; Hs.632239; - ProteinModelPortal; Q99583; - SMR; Q99583; - BioGrid; 110478; 16 ELM; Q99583; - IntAct; Q99583; 6 MINT; Q99583; - STRING; 9606.ENSP00000174618; - iPTMnet; Q99583; - PhosphoSitePlus; Q99583; - BioMuta; MNT; - DMDM; 3914034; - EPD; Q99583; - MaxQB; Q99583; - PaxDb; Q99583; - PeptideAtlas; Q99583; - PRIDE; Q99583; - ProteomicsDB; 78341; - Ensembl; ENST00000174618; ENSP00000174618; ENSG00000070444 GeneID; 4335; - KEGG; hsa:4335; - UCSC; uc002fur.4; human CTD; 4335; - DisGeNET; 4335; - EuPathDB; HostDB:ENSG00000070444.14; - GeneCards; MNT; - HGNC; HGNC:7188; MNT HPA; HPA059532; - HPA; HPA067578; - MIM; 603039; gene neXtProt; NX_Q99583; - OpenTargets; ENSG00000070444; - PharmGKB; PA30898; - eggNOG; KOG2483; Eukaryota eggNOG; ENOG4111VW9; LUCA GeneTree; ENSGT00510000048287; - HOGENOM; HOG000013115; - HOVERGEN; HBG006379; - InParanoid; Q99583; - KO; K09115; - OMA; AVIPMVP; - OrthoDB; EOG091G0PW2; - PhylomeDB; Q99583; - TreeFam; TF315654; - SIGNOR; Q99583; - ChiTaRS; MNT; human GeneWiki; MNT_(gene); - GenomeRNAi; 4335; - PRO; PR:Q99583; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000070444; - CleanEx; HS_MNT; - ExpressionAtlas; Q99583; baseline and differential Genevisible; Q99583; HS GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0003682; F:chromatin binding; IEA:Ensembl GO; GO:0003700; F:DNA binding transcription factor activity; TAS:ProtInc GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0003713; F:transcription coactivator activity; TAS:ProtInc GO; GO:0003714; F:transcription corepressor activity; TAS:ProtInc GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0007569; P:cell aging; IEA:Ensembl GO; GO:0007275; P:multicellular organism development; TAS:ProtInc GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl GO; GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Acetylation; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation INIT_MET 1 1 Removed. CHAIN 2 582 Max-binding protein MNT /FTId=PRO_0000127281 DOMAIN 220 271 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} REGION 271 299 Leucine-zipper MOD_RES 2 2 N-acetylserine VARIANT 109 109 A -> T (in dbSNP:rs7207965) /FTId=VAR_061258 SEQUENCE 582 AA; 62300 MW; 06AC320D79BF18A0 CRC64; MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA HTLPVEEPRM EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP LPPPPPLPAA AQPLPLAPRQ PALVGAPGLS IKEPAPLPSR PQVPTPAPLL PDSKATIPPN GSPKPLQPLP TPVLTIAPHP GVQPQLAPQQ PPPPTLGTLK LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF ETLKRNIPNV DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL GPPKLSHRPQ PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ QQPQQKTPLP APPPPPAAPA QTLVPAPAHL VATAGGGSTV IAHTATTHAS VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ LAPATPPIGH ITVHPATLNH VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT VMAKPAVGAQ VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA
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Background

This is a rabbit polyclonal antibody against MNT. It was validated on Western Blot by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).

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$ 295.00
Cat# AI10070
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