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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   LMX1A antibody - N-terminal region   

LMX1A antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - LMX1A antibody - N-terminal region AI10398
    WB Suggested Anti-LMX1A Antibody Titration: .2-1 μg/ml
    ELISA Titer: 1:125
    Positive Control: Human brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TE12
Other Accession NM_177398, NP_796372
Reactivity Human, Mouse, Rat, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Alias Symbol LMX-1, LMX1, LMX1.1, MGC87616
Other Names LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 1.1, LMX-1.1, LIM/homeobox protein LMX1A, LMX1A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-LMX1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLMX1A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMX1A
Function Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis. EMBL; AY078398; AAL82892.1; -; Genomic_DNA EMBL; AY078391; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078392; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078393; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078394; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078395; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078396; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078398; AAL82893.1; -; Genomic_DNA EMBL; AY078396; AAL82893.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82893.1; JOINED; Genomic_DNA EMBL; AK127724; BAG54558.1; -; mRNA EMBL; AL160058; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL390730; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471067; EAW90744.1; -; Genomic_DNA EMBL; BC119743; AAI19744.1; -; mRNA EMBL; BC119744; AAI19745.1; -; mRNA CCDS; CCDS1247.1; -. [Q8TE12-1] RefSeq; NP_001167540.1; NM_001174069.1. [Q8TE12-1] RefSeq; NP_796372.1; NM_177398.3. [Q8TE12-1] UniGene; Hs.667312; - ProteinModelPortal; Q8TE12; - SMR; Q8TE12; - BioGrid; 110194; 5 IntAct; Q8TE12; 1 STRING; 9606.ENSP00000294816; - iPTMnet; Q8TE12; - PhosphoSitePlus; Q8TE12; - BioMuta; LMX1A; - DMDM; 27923801; - PaxDb; Q8TE12; - PeptideAtlas; Q8TE12; - PRIDE; Q8TE12; - ProteomicsDB; 74389; - ProteomicsDB; 74390; -. [Q8TE12-2] DNASU; 4009; - Ensembl; ENST00000294816; ENSP00000294816; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000342310; ENSP00000340226; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000367893; ENSP00000356868; ENSG00000162761. [Q8TE12-1] GeneID; 4009; - KEGG; hsa:4009; - UCSC; uc001gcz.3; human. [Q8TE12-1] CTD; 4009; - DisGeNET; 4009; - EuPathDB; HostDB:ENSG00000162761.14; - GeneCards; LMX1A; - HGNC; HGNC:6653; LMX1A HPA; HPA028051; - HPA; HPA030088; - MIM; 600298; gene neXtProt; NX_Q8TE12; - OpenTargets; ENSG00000162761; - PharmGKB; PA30416; - eggNOG; KOG0490; Eukaryota eggNOG; ENOG410YIJ3; LUCA GeneTree; ENSGT00760000118921; - HOGENOM; HOG000231629; - HOVERGEN; HBG052335; - InParanoid; Q8TE12; - KO; K09371; - OMA; NDSLWHE; - OrthoDB; EOG091G09Z3; - PhylomeDB; Q8TE12; - TreeFam; TF315442; - SIGNOR; Q8TE12; - ChiTaRS; LMX1A; human GeneWiki; LMX1A; - GenomeRNAi; 4009; - PRO; PR:Q8TE12; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000162761; - CleanEx; HS_LMX1A; - Genevisible; Q8TE12; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:ParkinsonsUK-UCL GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0021549; P:cerebellum development; IEA:Ensembl GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl GO; GO:0071542; P:dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL GO; GO:0007626; P:locomotory behavior; IEA:Ensembl GO; GO:0007613; P:memory; IEA:Ensembl GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; ISS:ParkinsonsUK-UCL GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl GO; GO:0042048; P:olfactory behavior; IEA:Ensembl GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:ParkinsonsUK-UCL GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl GO; GO:0050808; P:synapse organization; IEA:Ensembl CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR017970; Homeobox_CS InterPro; IPR001356; Homeobox_dom InterPro; IPR001781; Znf_LIM Pfam; PF00046; Homeobox; 1 Pfam; PF00412; LIM; 2 SMART; SM00389; HOX; 1 SMART; SM00132; LIM; 2 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS00027; HOMEOBOX_1; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS00478; LIM_DOMAIN_1; 2 PROSITE; PS50023; LIM_DOMAIN_2; 2 1: Evidence at protein level; Activator; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc CHAIN 1 382 LIM homeobox transcription factor 1- alpha /FTId=PRO_0000075825 DOMAIN 33 92 LIM zinc-binding 1. {ECO:0000255|PROSITE- ProRule:PRU00125} DOMAIN 92 154 LIM zinc-binding 2. {ECO:0000255|PROSITE- ProRule:PRU00125} DNA_BIND 195 254 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} COMPBIAS 240 274 Gln-rich COMPBIAS 257 265 Poly-Gln VAR_SEQ 1 249 Missing (in isoform LMX1A-4AB) /FTId=VSP_003112 SEQUENCE 382 AA; 42747 MW; 55424762757FF5FD CRC64; MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
Research Areas
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Gregory,S.G., (2006) Nature 441 (7091), 315-321 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 295.00
Cat# AI10398
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