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>   home   >   Products   >   Primary Antibodies   >   HMG20A antibody - middle region   

HMG20A antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - HMG20A antibody - middle region AI10415
    WB Suggested Anti-HMG2A Antibody Titration: .2-1 μg/ml
    ELISA Titer: 1:3125
    Positive Control: 293T cell lysate

    HMG2A is supported by BioGPS gene expression data to be expressed in HEK293T

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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9NP66
Other Accession NM_018200, NP_060670
Reactivity Human, Mouse, Rat, Horse, Bovine, Dog
Predicted Rat, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Additional Information
Alias Symbol FLJ10739, HMGX1, HMGXB1
Other Names High mobility group protein 20A, HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1, HMG20A, HMGX1, HMGXB1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HMG20A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHMG20A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMG20A
Synonyms HMGX1, HMGXB1
Function Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}
Tissue Location Ubiquitous.. EMBL; AF146222; AAF66706.1; -; mRNA EMBL; AL355736; CAB90815.1; ALT_TERM; mRNA EMBL; AL355737; CAB90816.1; -; mRNA EMBL; AK001601; BAA91782.1; -; mRNA EMBL; BT006716; AAP35362.1; -; mRNA EMBL; AK223100; BAD96820.1; -; mRNA EMBL; AC090984; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471136; EAW99201.1; -; Genomic_DNA EMBL; CH471136; EAW99202.1; -; Genomic_DNA EMBL; CH471136; EAW99203.1; -; Genomic_DNA EMBL; BC021959; AAH21959.1; -; mRNA CCDS; CCDS10295.1; -. [Q9NP66-1] RefSeq; NP_001291433.1; NM_001304504.1. [Q9NP66-1] RefSeq; NP_001291434.1; NM_001304505.1 RefSeq; NP_060670.1; NM_018200.3. [Q9NP66-1] RefSeq; XP_011519460.1; XM_011521158.2. [Q9NP66-1] UniGene; Hs.69594; - ProteinModelPortal; Q9NP66; - SMR; Q9NP66; - BioGrid; 115643; 104 CORUM; Q9NP66; - IntAct; Q9NP66; 115 MINT; Q9NP66; - STRING; 9606.ENSP00000336856; - iPTMnet; Q9NP66; - PhosphoSitePlus; Q9NP66; - BioMuta; HMG20A; - DMDM; 74734297; - EPD; Q9NP66; - MaxQB; Q9NP66; - PaxDb; Q9NP66; - PeptideAtlas; Q9NP66; - PRIDE; Q9NP66; - ProteomicsDB; 81896; - ProteomicsDB; 81897; -. [Q9NP66-2] DNASU; 10363; - Ensembl; ENST00000336216; ENSP00000336856; ENSG00000140382. [Q9NP66-1] Ensembl; ENST00000381714; ENSP00000371133; ENSG00000140382. [Q9NP66-1] GeneID; 10363; - KEGG; hsa:10363; - UCSC; uc002bcr.4; human. [Q9NP66-1] CTD; 10363; - DisGeNET; 10363; - EuPathDB; HostDB:ENSG00000140382.14; - GeneCards; HMG20A; - HGNC; HGNC:5001; HMG20A HPA; HPA008126; - MIM; 605534; gene neXtProt; NX_Q9NP66; - OpenTargets; ENSG00000140382; - PharmGKB; PA29331; - eggNOG; KOG0381; Eukaryota eggNOG; COG5648; LUCA GeneTree; ENSGT00730000110938; - HOGENOM; HOG000247029; - HOVERGEN; HBG059870; - InParanoid; Q9NP66; - OMA; SYMKKLH; - OrthoDB; EOG091G0IHZ; - PhylomeDB; Q9NP66; - TreeFam; TF106440; - ChiTaRS; HMG20A; human GeneWiki; HMG20A; - GenomeRNAi; 10363; - PRO; PR:Q9NP66; - Proteomes; UP000005640; Chromosome 15 Bgee; ENSG00000140382; - CleanEx; HS_HMG20A; - ExpressionAtlas; Q9NP66; baseline and differential Genevisible; Q9NP66; HS GO; GO:0005634; C:nucleus; NAS:UniProtKB GO; GO:0003677; F:DNA binding; NAS:UniProtKB GO; GO:0003700; F:DNA binding transcription factor activity; NAS:UniProtKB GO; GO:0042802; F:identical protein binding; IPI:IntAct GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0006325; P:chromatin organization; NAS:UniProtKB GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl GO; GO:0033234; P:negative regulation of protein sumoylation; IEA:Ensembl GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf Pfam; PF00505; HMG_box; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 1: Evidence at protein level; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation CHAIN 1 347 High mobility group protein 20A /FTId=PRO_0000238649 DNA_BIND 103 171 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} COILED 229 273 MOD_RES 105 105 Phosphoserine VAR_SEQ 80 81 QR -> VS (in isoform 2) {ECO:0000303|Ref.2} /FTId=VSP_018621 VAR_SEQ 82 347 Missing (in isoform 2) {ECO:0000303|Ref.2} /FTId=VSP_018622 CONFLICT 320 320 L -> P (in Ref. 5; BAD96820) SEQUENCE 347 AA; 40144 MW; D8632FFAAA162587 CRC64; MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE FVEDLSQGQL LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS NAPKSPLTGY VRFMNERREQ LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ RYLDEADRDK ERYMKELEQY QKTEAYKVFS RKTQDRQKGK SHRQDAARQA THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR KSNMEFEERN AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR
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References

Rual,J.F., et al., (2005) Nature 437 (7062), 1173-1178Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 295.00
Cat# AI10415
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