|Other Accession||NM_013448, NP_038476|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Bovine, Guinea Pig, Dog|
|Alias Symbol||ACF1, DKFZP586E0518, FLJ14383, WALp1, WCRF180, hACF1|
|Other Names||Bromodomain adjacent to zinc finger domain protein 1A, ATP-dependent chromatin-remodeling protein, ATP-utilizing chromatin assembly and remodeling factor 1, hACF1, CHRAC subunit ACF1, Williams syndrome transcription factor-related chromatin-remodeling factor 180, WCRF180, hWALp1, BAZ1A, ACF1, WCRF180|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-BAZ1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||BAZ1A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.|
|Cellular Location||Nucleus. Note=May target the CHRAC complex to heterochromatin|
|Tissue Location||Highly expressed in testis and at low or undetectable levels in other tissues analyzed|
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Provided below are standard protocols that you may find useful for product applications.
Ewing,A.K., (2007) Mol. Endocrinol. 21 (8), 1791-1806 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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