|Application ||WB, IHC|
|Other Accession||NM_003662, NP_003653|
|Reactivity||Human, Mouse, Rat, Pig, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Bovine, Dog|
|Other Names||Pirin, 220.127.116.11, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-PIR antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PIR antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).|
|Cellular Location||Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression|
|Tissue Location||Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level) Expressed in all tissues, with highest level of expression in heart and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Adams,M. (2005) J. Biol. Chem. 280 (31), 28675-28682 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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