|Application ||WB, IHC|
|Other Accession||NM_001181, NP_001172|
|Alias Symbol||HL-2, HBXBP, ASGPR2, ASGP-R2, CLEC4H2|
|Other Names||Asialoglycoprotein receptor 2, ASGP-R 2, ASGPR 2, C-type lectin domain family 4 member H2, Hepatic lectin H2, HL-2, ASGR2, CLEC4H2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-ASGR2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ASGR2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed exclusively in hepatic parenchymal cells|
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Provided below are standard protocols that you may find useful for product applications.
Yik,J.H.,et al., (2002) J.Biol.Chem.277(43),40844-40852Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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