|Other Accession||NM_152577, NP_689790|
|Other Names||E3 ubiquitin-protein ligase ZNF645, 6.3.2.-, Zinc finger protein 645, ZNF645|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ZNF645 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ZNF645 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131).|
|Cellular Location||Cytoplasm. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail.|
|Tissue Location||Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.|
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Provided below are standard protocols that you may find useful for product applications.
Sugano,S. Unpublished (2002)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Bai, G. et al. Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene. BMB Rep. 43, 400-6 (2010). WB, IHC, Human20587329Liu, Y.-Q. et al. Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase. Asian J. Androl. 12, 658-66 (2010). WB, Human20657603
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