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>   home   >   Products   >   Primary Antibodies   >   Noto antibody - N-terminal region   

Noto antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Noto antibody - N-terminal region AI11033

    WB Suggested Anti-Noto Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: Mouse Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A8MTQ0
Other Accession NM_001007472, NP_001007473
Reactivity Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog
Predicted Mouse, Rabbit, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Additional Information
Alias Symbol Flh, MmNot, Not, tc
Other Names Homeobox protein notochord, NOTO
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Noto antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsNoto antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108} EMBL; AK295936; BAG58721.1; -; mRNA EMBL; AK316410; BAH14781.1; -; mRNA EMBL; AC010913; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS46335.1; - RefSeq; NP_001127934.1; NM_001134462.1 UniGene; Hs.694384; - ProteinModelPortal; A8MTQ0; - SMR; A8MTQ0; - IntAct; A8MTQ0; 32 STRING; 9606.ENSP00000381486; - iPTMnet; A8MTQ0; - PhosphoSitePlus; A8MTQ0; - BioMuta; NOTO; - PaxDb; A8MTQ0; - PRIDE; A8MTQ0; - ProteomicsDB; 2043; - Ensembl; ENST00000398468; ENSP00000381486; ENSG00000214513 GeneID; 344022; - KEGG; hsa:344022; - UCSC; uc010yrd.3; human CTD; 344022; - EuPathDB; HostDB:ENSG00000214513.3; - GeneCards; NOTO; - HGNC; HGNC:31839; NOTO HPA; HPA034660; - neXtProt; NX_A8MTQ0; - OpenTargets; ENSG00000214513; - PharmGKB; PA134895171; - eggNOG; KOG0843; Eukaryota eggNOG; ENOG4111SRW; LUCA GeneTree; ENSGT00910000144043; - HOGENOM; HOG000082431; - HOVERGEN; HBG108196; - InParanoid; A8MTQ0; - OMA; YPVPGPR; - OrthoDB; EOG091G0M18; - PhylomeDB; A8MTQ0; - TreeFam; TF326858; - GenomeRNAi; 344022; - PRO; PR:A8MTQ0; - Proteomes; UP000005640; Chromosome 2 Bgee; ENSG00000214513; - CleanEx; HS_NOTO; - GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl GO; GO:0001947; P:heart looping; IEA:Ensembl GO; GO:0044458; P:motile cilium assembly; IEA:Ensembl GO; GO:0030903; P:notochord development; IEA:Ensembl GO; GO:1902017; P:regulation of cilium assembly; IEA:Ensembl GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001356; Homeobox_dom Pfam; PF00046; Homeobox; 1 SMART; SM00389; HOX; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS50071; HOMEOBOX_2; 1 2: Evidence at transcript level; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 251 Homeobox protein notochord /FTId=PRO_0000343223 DNA_BIND 156 215 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} COMPBIAS 2 68 Pro-rich VARIANT 5 5 R -> T (in dbSNP:rs1864492) /FTId=VAR_059353 VARIANT 164 164 N -> K (in dbSNP:rs13418681) /FTId=VAR_059354 SEQUENCE 251 AA; 27003 MW; 56BBB3E0E6B5B092 CRC64; MPSPRPRGSP PPAPSGSRVR PPRSGRSPAP RSPTGPNTPR APGRFESPFS VEAILARPDP CAPAASQPSG SACVHPAFWT AASLCATGGL PWACPTSWLP AYLSVGFYPV PGPRVAPVCG LLGFGVTGLE LAHCSGLWAF PDWAPTEDLQ DTERQQKRVR TMFNLEQLEE LEKVFAKQHN LVGKKRAQLA ARLKLTENQV RVWFQNRRVK YQKQQKLRAA VTSAEAASLD EPSSSSIASI QSDDAESGVD G
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$ 295.00
Cat# AI11033
Availability: 2-3 days
Bulk Size
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