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PTRF antibody - middle region

Rabbit Polyclonal Antibody

     
  • IHC - PTRF antibody - middle region AI11078
    IHC Information: Paraffin embedded mouse vessel and adipocytes (skeletal muscle) tissue, tested with an antibody Dilution of 5 μg/ml.
  • WB - PTRF antibody - middle region AI11078

    WB Suggested Anti-PTRF Antibody Titration: 0.625μg/ml
    ELISA Titer: 1:312500
    Positive Control: NIH/3T3 cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession O54724
Other Accession NM_008986, NP_033012
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Gene ID 19285
Alias Symbol Cavin, Cav-p60, AW546441, 2310075E07Rik
Other Names Polymerase I and transcript release factor, Cav-p60, Cavin-1, Ptrf {ECO:0000312|MGI:MGI:1277968}
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-PTRF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPTRF antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cavin1
Synonyms Ptrf {ECO:0000312|MGI:MGI:1277968}
Function Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612).
Cellular Location Membrane, caveola. Cell membrane. Microsome {ECO:0000250|UniProtKB:Q6NZI2}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P85125}. Cytoplasm, cytosol Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242) {ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:19546242}
Tissue Location Expressed in the heart, stomach, adipose tissue and lung (at protein level). Expressed in testis, kidney, muscle, liver, spleen and brain.
Citations (0)

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References

Miyoshi,K., et al., (2001) Genomics 71 (2), 150-155Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 235.00
Cat# AI11078
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