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>   home   >   Products   >   Primary Antibodies   >   RAD51AP1 antibody - middle region   

RAD51AP1 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - RAD51AP1 antibody - middle region AI11778

    WB Suggested Anti-RAD51AP1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: HT1080 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96B01
Other Accession NM_006479, NP_006470
Reactivity Human, Rat, Rabbit, Pig, Horse, Yeast, Dog
Predicted Human, Rabbit, Pig, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Additional Information
Alias Symbol PIR51
Other Names RAD51-associated protein 1, RAD51-interacting protein, R51A1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-RAD51AP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRAD51AP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name R51A1
Function May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.
Cellular Location Nucleus. Note=Colocalizes with RAD51 to multiple nuclear foci.
Tissue Location Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes EMBL; AF006259; AAC39554.1; -; mRNA EMBL; AK096930; BAC04902.1; -; mRNA EMBL; AK291948; BAF84637.1; -; mRNA EMBL; CH471116; EAW88844.1; -; Genomic_DNA EMBL; BC006992; AAH06992.1; -; mRNA EMBL; BC016330; AAH16330.1; -; mRNA CCDS; CCDS44805.1; -. [Q96B01-1] CCDS; CCDS8529.1; -. [Q96B01-2] RefSeq; NP_001124334.1; NM_001130862.1. [Q96B01-1] RefSeq; NP_006470.1; NM_006479.4. [Q96B01-2] UniGene; Hs.730696; - ProteinModelPortal; Q96B01; - BioGrid; 115879; 15 DIP; DIP-35257N; - IntAct; Q96B01; 12 STRING; 9606.ENSP00000228843; - iPTMnet; Q96B01; - PhosphoSitePlus; Q96B01; - BioMuta; RAD51AP1; - DMDM; 68565925; - EPD; Q96B01; - jPOST; Q96B01; - MaxQB; Q96B01; - PaxDb; Q96B01; - PeptideAtlas; Q96B01; - PRIDE; Q96B01; - ProteomicsDB; 76027; - ProteomicsDB; 76028; -. [Q96B01-2] ProteomicsDB; 76029; -. [Q96B01-3] TopDownProteomics; Q96B01-1; -. [Q96B01-1] DNASU; 10635; - Ensembl; ENST00000228843; ENSP00000228843; ENSG00000111247. [Q96B01-1] Ensembl; ENST00000352618; ENSP00000309479; ENSG00000111247. [Q96B01-2] GeneID; 10635; - KEGG; hsa:10635; - UCSC; uc001qmu.4; human. [Q96B01-1] CTD; 10635; - DisGeNET; 10635; - EuPathDB; HostDB:ENSG00000111247.14; - GeneCards; RAD51AP1; - HGNC; HGNC:16956; RAD51AP1 HPA; HPA051499; - MIM; 603070; gene neXtProt; NX_Q96B01; - OpenTargets; ENSG00000111247; - PharmGKB; PA134871784; - eggNOG; ENOG410IICA; Eukaryota eggNOG; ENOG4111WAW; LUCA GeneTree; ENSGT00940000153414; - HOGENOM; HOG000116153; - HOVERGEN; HBG079699; - InParanoid; Q96B01; - KO; K20778; - OMA; GRIPKWN; - OrthoDB; 1109145at2759; - PhylomeDB; Q96B01; - TreeFam; TF335955; - Reactome; R-HSA-5685942; HDR through Homologous Recombination (HRR) Reactome; R-HSA-5693554; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Reactome; R-HSA-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates Reactome; R-HSA-5693579; Homologous DNA Pairing and Strand Exchange ChiTaRS; RAD51AP1; human GenomeRNAi; 10635; - PRO; PR:Q96B01; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000111247; Expressed in 170 organ(s), highest expression level in secondary oocyte ExpressionAtlas; Q96B01; baseline and differential Genevisible; Q96B01; HS GO; GO:0000790; C:nuclear chromatin; IDA:ParkinsonsUK-UCL GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0005634; C:nucleus; IDA:ParkinsonsUK-UCL GO; GO:0032991; C:protein-containing complex; IMP:UniProtKB GO; GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB GO; GO:0003723; F:RNA binding; IDA:UniProtKB GO; GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB GO; GO:0071479; P:cellular response to ionizing radiation; IDA:UniProtKB GO; GO:0006281; P:DNA repair; TAS:ProtInc GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:ParkinsonsUK-UCL GO; GO:0036297; P:interstrand cross-link repair; IMP:ParkinsonsUK-UCL GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IDA:UniProtKB InterPro; IPR026632; RAD51-assoc_prot_1 InterPro; IPR031419; RAD51_interact PANTHER; PTHR15361:SF4; PTHR15361:SF4; 1 Pfam; PF15696; RAD51_interact; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding CHAIN 1 352 RAD51-associated protein 1 /FTId=PRO_0000097140 REGION 313 352 Interaction with RAD51 MOD_RES 19 19 Phosphoserine MOD_RES 21 21 Phosphoserine MOD_RES 66 66 Phosphothreonine MOD_RES 120 120 Phosphoserine MOD_RES 124 124 Phosphoserine MOD_RES 280 280 Phosphoserine MOD_RES 327 327 Phosphoserine VAR_SEQ 71 87 Missing (in isoform 2) /FTId=VSP_051739 VAR_SEQ 258 307 Missing (in isoform 3) /FTId=VSP_051740 VARIANT 68 68 K -> Q (in dbSNP:rs34810644) /FTId=VAR_056976 MUTAGEN 333 333 R->A: Strongly decreases interaction with RAD51; when associated with Q-336; A-345 and A-346. MUTAGEN 336 336 L->Q: Strongly decreases interaction with RAD51; when associated with A-333; A-345 and A-346. MUTAGEN 345 346 LH->AA: Strongly decreases interaction with RAD51; when associated with A-333; and Q-336. SEQUENCE 352 AA; 38457 MW; E582EE4BC459DD92 CRC64; MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP KELKQDKPKP NLNNLRKEEI PVQEKTPKKR LPEGTFSIPA SAVPCTKMAL DDKLYQRDLE VALALSVKEL PTVTTNVQNS QDKSIEKHGS SKIETMNKSP HISNCSVASD YLDLDKITVE DDVGGVQGKR KAASKAAAQQ RKILLEGSDG DSANDTEPDF APGEDSEDDS DFCESEDNDE DFSMRKSKVK EIKKKEVKVK SPVEKKEKKS KSKCNALVTS VDSAPAAVKS ESQSLPKKVS LSSDTTRKPL EIRSPSAESK KPKWVPPAAS GGSRSSSSPL VVVSVKSPNQ SLRLGLSRLA RVKPLHPNAT ST
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Obama,K., (2008) Clin. Cancer Res. 14 (5), 1333-1339 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 295.00
Cat# AI11778
Availability: 2-3 days
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