|Other Accession||NM_023670, NP_076159|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Dog|
|Alias Symbol||2610101N11Rik, AA522010, AL022933, AU045931, IMP-3, IMP3, Koc13, MGC61294, Neilsen, mimp3|
|Other Names||Insulin-like growth factor 2 mRNA-binding protein 3, IGF2 mRNA-binding protein 3, IMP-3, mIMP-3, IGF-II mRNA-binding protein 3, VICKZ family member 3, Igf2bp3, Vickz3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Igf2bp3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Igf2bp3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta- actin/ACTB and MYC transcripts (By similarity). Binds to the 5'- UTR of the insulin-like growth factor 2 (IGF2) mRNAs.|
|Cellular Location||Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth Localized at the connecting piece and the tail of the spermatozoa In response to cellular stress, such as oxidative stress, recruited to stress granules.|
|Tissue Location||Expressed in oocytes, spermatogonia and spermatocytes (at protein level).|
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