|Other Accession||NM_014494, NP_055309|
|Reactivity||Human, Mouse, Horse, Dog|
|Predicted||Mouse, Rat, Chicken, Horse, Dog|
|Alias Symbol||CAGH26, DKFZp666E117, FLJ22043, GW1, GW182, KIAA1460, MGC75384, TNRC6|
|Other Names||Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa, TNRC6A, CAGH26, KIAA1460, TNRC6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TNRC6A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TNRC6A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAGH26, KIAA1460, TNRC6|
|Function||Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.|
|Cellular Location||Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs)|
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Provided below are standard protocols that you may find useful for product applications.
Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). WB, H, Mouse, Human, Dog22898980
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