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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LASS4 antibody - N-terminal region   

LASS4 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - LASS4 antibody - N-terminal region AI12054

    WB Suggested Anti-LASS4 Antibody Titration: 2.5μg/ml
    ELISA Titer: 1:312500
    Positive Control: NIH/3T3 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9D6J1
Other Accession NM_026058, NP_080334
Reactivity Mouse, Rat, Guinea Pig
Predicted Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Alias Symbol Trh1, CerS4, 2900019C14Rik, LASS4
Other Names Ceramide synthase 4, CerS4, LAG1 longevity assurance homolog 4, Translocating chain-associating membrane protein homolog 1, TRAM homolog 1, Cers4, Lass4, Trh1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-LASS4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLASS4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cers4
Synonyms Lass4, Trh1
Function May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.
Cellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Ubiquitously expressed, with highest levels in skin. EMBL; AY029531; AAK40299.1; -; mRNA EMBL; AK013554; BAB28903.1; -; mRNA EMBL; AK021316; BAB32370.3; -; mRNA EMBL; AK028937; BAC26202.1; -; mRNA EMBL; AK028945; BAC26208.1; -; mRNA EMBL; AK030280; BAC26876.1; -; mRNA EMBL; BC003946; AAH03946.1; -; mRNA CCDS; CCDS22086.1; - RefSeq; NP_080334.3; NM_026058.4 RefSeq; XP_006508924.1; XM_006508861.3 RefSeq; XP_006508925.1; XM_006508862.3 RefSeq; XP_006508926.1; XM_006508863.3 UniGene; Mm.35511; - ProteinModelPortal; Q9D6J1; - SMR; Q9D6J1; - BioGrid; 212053; 1 STRING; 10090.ENSMUSP00000008350; - SwissLipids; SLP:000000117; - iPTMnet; Q9D6J1; - PhosphoSitePlus; Q9D6J1; - MaxQB; Q9D6J1; - PaxDb; Q9D6J1; - PeptideAtlas; Q9D6J1; - PRIDE; Q9D6J1; - Ensembl; ENSMUST00000008350; ENSMUSP00000008350; ENSMUSG00000008206 GeneID; 67260; - KEGG; mmu:67260; - UCSC; uc009ktx.2; mouse CTD; 79603; - MGI; MGI:1914510; Cers4 eggNOG; KOG1607; Eukaryota eggNOG; COG5058; LUCA GeneTree; ENSGT00550000074401; - HOVERGEN; HBG052310; - InParanoid; Q9D6J1; - KO; K04710; - OMA; LYHESWL; - OrthoDB; EOG091G0BWM; - PhylomeDB; Q9D6J1; - TreeFam; TF314319; - BRENDA; 2.3.1.24; 3474 Reactome; R-MMU-1660661; Sphingolipid de novo biosynthesis PRO; PR:Q9D6J1; - Proteomes; UP000000589; Chromosome 8 Bgee; ENSMUSG00000008206; - CleanEx; MM_LASS4; - ExpressionAtlas; Q9D6J1; baseline and differential Genevisible; Q9D6J1; MM GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0050291; F:sphingosine N-acyltransferase activity; IDA:MGI GO; GO:0046513; P:ceramide biosynthetic process; IDA:MGI GO; GO:0030148; P:sphingolipid biosynthetic process; IDA:MGI CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001356; Homeobox_dom InterPro; IPR016439; Lag1/Lac1-like InterPro; IPR006634; TLC-dom PANTHER; PTHR12560; PTHR12560; 1 Pfam; PF00046; Homeobox; 1 Pfam; PF03798; TRAM_LAG1_CLN8; 1 PIRSF; PIRSF005225; LAG1_LAC1; 1 SMART; SM00724; TLC; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS50922; TLC; 1 1: Evidence at protein level; Complete proteome; DNA-binding; Endoplasmic reticulum; Homeobox; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 393 Ceramide synthase 4 /FTId=PRO_0000185513 TRANSMEM 32 52 Helical. TRANSMEM 140 160 Helical. TRANSMEM 179 199 Helical. TRANSMEM 217 237 Helical. TRANSMEM 265 285 Helical. TRANSMEM 304 324 Helical. DOMAIN 131 332 TLC. {ECO:0000255|PROSITE- ProRule:PRU00205} DNA_BIND 67 128 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} MOD_RES 342 342 Phosphoserine MOD_RES 349 349 Phosphoserine MOD_RES 350 350 Phosphoserine CONFLICT 19 19 N -> S (in Ref. 2; BAC26208) CONFLICT 237 237 L -> M (in Ref. 2; BAB32370) SEQUENCE 393 AA; 46017 MW; B2038F7A128F816F CRC64; MSFSLSEWLW QETYWLPPNV TWAELEDRDG LVFAHPHHVL AAFPVALVLV AVRIVFERFV ALPLSRWMGV QDPIRRKIKP NPVLEKYFLR MKQCPEETQM VLLASQCGLT LRQTQRWFRR RRNQDRPSLS KKFCEACWRF VFYLCSFVGG TSILYHESWL WSPSLCWENY PHQTLNLSLY WWYLLELGFY LSLLITLPFD VKRKDFKEQV VHHFVAVGLI GFSYSVNLLR IGAVVLLLHD CSDYLLEGCK ILNYAHFRRG CDALFIMFAL VFFYTRLIFF PTQVIYTSVY DSIKNSGPFF GYYFFIVLLV MLQILHVYWF CLILRMLYSF LHKGQMTEDI RSDVEEPDSS DDEPVSEGPQ LKNGMARGSR VAVTNGPRSR AAACLTNGHT RAT
Research Areas
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References

Riebeling,C.,etal.,(2003)J.Biol.Chem.278(44),43452-43459ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.

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$ 235.00
Cat# AI12054
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