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>   home   >   Products   >   Primary Antibodies   >   Slc9a3r2 antibody - N-terminal region   

Slc9a3r2 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Slc9a3r2 antibody - N-terminal region AI12343

    WB Suggested Anti-Slc9a3r2 Antibody Titration: 1.0 μg/ml
    Positive Control: Rat Brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q920G2
Other Accession NM_053811, NP_446263
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Additional Information
Alias Symbol E3karp
Other Names Na(+)/H(+) exchange regulatory cofactor NHE-RF2, NHERF-2, NHE3 kinase A regulatory protein E3KARP, SRY-interacting protein 1, SIP-1, Sodium-hydrogen exchanger regulatory factor 2, Solute carrier family 9 isoform A3 regulatory factor 2, Tyrosine kinase activator protein 1, TKA-1, Slc9a3r2, Nherf2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Slc9a3r2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSlc9a3r2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Slc9a3r2
Synonyms Nherf2
Function Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.
Cellular Location Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane. Note=Nuclear, in a punctate pattern. Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes
Tissue Location Glomerular epithelium cell (podocyte) (at protein level). Detected in liver, bile duct, kidney glomerulus and lung. EMBL; AF294257; AAK97088.1; -; mRNA EMBL; AF259898; AAK49392.1; -; mRNA RefSeq; NP_446263.2; NM_053811.3 UniGene; Rn.39351; - ProteinModelPortal; Q920G2; - SMR; Q920G2; - BioGrid; 250471; 1 CORUM; Q920G2; - IntAct; Q920G2; 1 STRING; 10116.ENSRNOP00000004172; - iPTMnet; Q920G2; - PhosphoSitePlus; Q920G2; - PaxDb; Q920G2; - PRIDE; Q920G2; - GeneID; 116501; - KEGG; rno:116501; - UCSC; RGD:620380; rat CTD; 9351; - RGD; 620380; Slc9a3r2 eggNOG; ENOG410ITAC; Eukaryota eggNOG; ENOG4111V58; LUCA HOGENOM; HOG000089940; - HOVERGEN; HBG052616; - InParanoid; Q920G2; - KO; K13358; - PhylomeDB; Q920G2; - PRO; PR:Q920G2; - Proteomes; UP000002494; Unplaced GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB GO; GO:0005737; C:cytoplasm; IDA:RGD GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IDA:RGD GO; GO:0005886; C:plasma membrane; IDA:RGD GO; GO:0032991; C:protein-containing complex; IDA:RGD GO; GO:0016247; F:channel regulator activity; IMP:RGD GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IPI:RGD GO; GO:0030165; F:PDZ domain binding; IMP:RGD GO; GO:0032947; F:protein-containing complex scaffold activity; IMP:RGD GO; GO:0048839; P:inner ear development; IEP:RGD GO; GO:0045838; P:positive regulation of membrane potential; IDA:RGD InterPro; IPR015098; EBP50_C-term InterPro; IPR017300; NHERF-1/NHERF-2 InterPro; IPR031197; NHERF-2 InterPro; IPR001478; PDZ InterPro; IPR036034; PDZ_sf PANTHER; PTHR14191:SF4; PTHR14191:SF4; 1 Pfam; PF09007; EBP50_C; 2 Pfam; PF00595; PDZ; 2 PIRSF; PIRSF037866; EBP50; 1 ProDom; PD283022; EBP50_C-term; 1 SMART; SM00228; PDZ; 2 SUPFAM; SSF50156; SSF50156; 2 PROSITE; PS50106; PDZ; 2 1: Evidence at protein level; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat CHAIN 1 337 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 /FTId=PRO_0000096808 DOMAIN 11 91 PDZ 1. {ECO:0000255|PROSITE- ProRule:PRU00143} DOMAIN 151 231 PDZ 2. {ECO:0000255|PROSITE- ProRule:PRU00143} MOD_RES 130 130 Phosphoserine {ECO:0000250|UniProtKB:Q9JHL1} MOD_RES 183 183 Phosphoserine {ECO:0000250|UniProtKB:Q15599} MOD_RES 186 186 Phosphoserine MOD_RES 254 254 Phosphoserine {ECO:0000250|UniProtKB:Q15599} MOD_RES 269 269 Phosphoserine {ECO:0000250|UniProtKB:Q9JHL1} MOD_RES 280 280 Phosphoserine MOD_RES 303 303 Phosphoserine {ECO:0000250|UniProtKB:Q15599} CONFLICT 74 74 H -> Q (in Ref. 2; AAK49392) CONFLICT 137 137 H -> Q (in Ref. 2; AAK49392) SEQUENCE 337 AA; 37369 MW; C4B8E6D0CCFDBB0E CRC64; MAAPESLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN GVNVEGETHH QVVHRIKAVE GQTQLLVVDK ETDEELCRRQ LTCTEEMAHR GLPPAHNPWE PKPDWACSGS LGSDTGHKDV NGPPRELRPR LCHLRRGPQG YGFNLHSDKS RPGQYIRSVD PGSPASLSGL RAQDRLIEVN GQNVEGLRHA EVVARIKAQE DEARLLVVDP ETDEHFKRLR VVPTEDHVEG PLPSPVTNGT SLAQLNGGSV CSSRSDLPGS EKDNEDGSAW KRDPFQESGL HLSPTAAEAK EKARATRVNK RAPQMDWNRK REIFSNF
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$ 295.00
Cat# AI12343
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