|Other Accession||NM_008595, NP_032621|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Beta-1, 3-N-acetylglucosaminyltransferase manic fringe, 18.104.22.168, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, Mfng|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mfng antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mfng antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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