|Other Accession||NM_014616, NP_055431|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Chicken, Horse, Bovine, Guinea Pig|
|Alias Symbol||ATPIF, ATPIR, DKFZP434J238, DKFZP434N1615, KIAA0956, MGC46576|
|Other Names||Probable phospholipid-transporting ATPase IF, 22.214.171.124, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B, ATP11B, ATPIF, ATPIR, KIAA0956|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ATP11B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ATP11B antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATPIF, ATPIR, KIAA0956|
|Function||Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.|
|Cellular Location||Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794)|
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