|Other Accession||NM_022787, NP_073624|
|Reactivity||Human, Mouse, Rat, Rabbit, Goat, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Guinea Pig|
|Alias Symbol||NMNAT, PNAT-1, PNAT1|
|Other Names||Nicotinamide mononucleotide adenylyltransferase 1, NMN adenylyltransferase 1, 188.8.131.52, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1, 184.108.40.206, NMNAT1, NMNAT|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-NMNAT1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NMNAT1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity).|
|Tissue Location||Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain|
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Provided below are standard protocols that you may find useful for product applications.
Schweiger M.,et al.FEBS Lett. 492:95-100(2001).
Emanuelli M.,et al.J. Biol. Chem. 276:406-412(2001).
Fernando F.S.,et al.Gene 284:23-29(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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