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>   home   >   Products   >   Primary Antibodies   >   LRRC59 antibody - N-terminal region   

LRRC59 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - LRRC59 antibody - N-terminal region AI13015

    WB Suggested Anti-LRRC59 Antibody Titration: 1 μg/ml
    Positive Control: Fetal Lung cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5RJR8
Other Accession NM_018509, NP_060979
Reactivity Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog
Predicted Mouse, Rabbit, Pig, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Additional Information
Alias Symbol FLJ21675, PRO1855
Other Names Leucine-rich repeat-containing protein 59, Protein p34, Lrrc59, Rbp34
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-LRRC59 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLRRC59 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lrrc59
Synonyms Rbp34
Function Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).
Cellular Location Microsome membrane; Single- pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. EMBL; D13623; BAA02786.1; -; mRNA EMBL; BC086530; AAH86530.1; -; mRNA RefSeq; NP_001008281.1; NM_001008280.1 UniGene; Rn.2783; - ProteinModelPortal; Q5RJR8; - SMR; Q5RJR8; - BioGrid; 252266; 1 STRING; 10116.ENSRNOP00000004941; - iPTMnet; Q5RJR8; - PhosphoSitePlus; Q5RJR8; - PaxDb; Q5RJR8; - PRIDE; Q5RJR8; - Ensembl; ENSRNOT00000004941; ENSRNOP00000004941; ENSRNOG00000003524 GeneID; 287633; - KEGG; rno:287633; - UCSC; RGD:1305092; rat CTD; 55379; - RGD; 1305092; Lrrc59 eggNOG; KOG0473; Eukaryota eggNOG; ENOG4111GH4; LUCA GeneTree; ENSGT00390000017385; - HOGENOM; HOG000073534; - HOVERGEN; HBG081933; - InParanoid; Q5RJR8; - OMA; KAAGDCL; - OrthoDB; EOG091G0EHN; - PhylomeDB; Q5RJR8; - TreeFam; TF316929; - PRO; PR:Q5RJR8; - Proteomes; UP000002494; Chromosome 10 Bgee; ENSRNOG00000003524; - Genevisible; Q5RJR8; RN GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell Gene3D;; -; 1 InterPro; IPR001611; Leu-rich_rpt InterPro; IPR003591; Leu-rich_rpt_typical-subtyp InterPro; IPR032675; LRR_dom_sf Pfam; PF13855; LRR_8; 1 SMART; SM00369; LRR_TYP; 4 PROSITE; PS51450; LRR; 4 1: Evidence at protein level; Acetylation; Coiled coil; Complete proteome; Endoplasmic reticulum; Leucine-rich repeat; Membrane; Microsome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix CHAIN 1 307 Leucine-rich repeat-containing protein 59 /FTId=PRO_0000235161 INIT_MET 1 1 Removed; alternate {ECO:0000250|UniProtKB:Q96AG4} CHAIN 2 307 Leucine-rich repeat-containing protein 59, N-terminally processed /FTId=PRO_0000441741 TOPO_DOM 2 244 Cytoplasmic. TRANSMEM 245 265 Helical. TOPO_DOM 266 307 Lumenal. REPEAT 10 31 LRR 1 REPEAT 40 62 LRR 2 REPEAT 63 84 LRR 3 REPEAT 86 107 LRR 4 REPEAT 109 128 LRR 5 COILED 148 216 COMPBIAS 251 257 Poly-Leu MOD_RES 1 1 N-acetylmethionine {ECO:0000250|UniProtKB:Q96AG4} MOD_RES 2 2 N-acetylthreonine; in Leucine-rich repeat-containing protein 59, N- terminally processed {ECO:0000250|UniProtKB:Q96AG4} MOD_RES 23 23 Phosphoserine {ECO:0000250|UniProtKB:Q96AG4} MOD_RES 25 25 Phosphoserine {ECO:0000250|UniProtKB:Q96AG4} MOD_RES 73 73 N6-succinyllysine {ECO:0000250|UniProtKB:Q922Q8} MOD_RES 135 135 N6-acetyllysine {ECO:0000250|UniProtKB:Q922Q8} SEQUENCE 307 AA; 34869 MW; BCAD25C593C1FE89 CRC64; MTKTGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATVLDLSCNK LSTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNRLVTL PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQQAK EAKERELRKR EKAEEKERRR KEYDAQKASK REQEKKPKKE TNQAPKSKSG SRPRKPPPRK HNRSWAVLKG LLLLLLLCVA GGLVVCRVTG LQQQPLCTSV NAIYDNAVQG LRHHEILQWV LQTDSQQ
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Ohsumi T.,et al.Biochem. J. 294:465-472(1993).

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$ 295.00
Cat# AI13015
Availability: 2-3 days
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