|Other Accession||NM_019026, NP_061899|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Bovine, Dog|
|Alias Symbol||HP10122, PCIA3, PNAS-136, RP11-466F5.7, TMCC4|
|Other Names||Transmembrane and coiled-coil domain-containing protein 1, Transmembrane and coiled-coil domains protein 4, Xenogeneic cross-immune protein PCIA3, TMCO1, TMCC4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-TMCO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TMCO1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed:27212239). A publication reported localization in cytoplasm and nucleus (PubMed:22714896). Nuclear localization is however in contradiction with two other reports (PubMed:10393320, PubMed:27212239).|
|Tissue Location||Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed:22714896).|
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Provided below are standard protocols that you may find useful for product applications.
Iwamuro S.,et al.J. Biochem. 126:48-53(1999).
Deng H.-X.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Yu W.-Q.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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