|Other Accession||NM_023935, NP_076424|
|Reactivity||Human, Rabbit, Horse, Bovine, Dog|
|Predicted||Human, Rabbit, Horse, Bovine, Dog|
|Alias Symbol||MGC2592, dJ1187M17.3, UFBP1, C20orf116|
|Other Names||DDRGK domain-containing protein 1, UFM1-binding and PCI domain-containing protein 1, DDRGK1 (HGNC:16110)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-C20orf116 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||C20orf116 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity).|
|Cellular Location||Endoplasmic reticulum|
|Tissue Location||Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.|
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Provided below are standard protocols that you may find useful for product applications.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tatsumi K.,et al.J. Biol. Chem. 285:5417-5427(2010).
Wu J.,et al.J. Biol. Chem. 285:15126-15136(2010).
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