|Other Accession||NM_028444, NP_082720|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Guinea Pig, Dog|
|Alias Symbol||3110015B12Rik, 6330514M23Rik, MGC6598, SRBC|
|Other Names||Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, Prkcdbp, Srbc|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Prkcdbp antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Prkcdbp Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed: 28285351, PubMed:23652019). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727).|
|Cellular Location||Cytoplasm. Cytoplasm, cytosol. Membrane, caveola. Note=Localizes in the caveolae in a caveolin-dependent manner.|
|Tissue Location||Lung, heart, skeletal muscle, liver, brain, vascular and urinary bladder smooth muscle (at protein level) Strongly expressed in uterus, ovary, mammary and epithelial cells Also expressed in spleen, intestine, kidney and testis|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Izumi Y.,et al.J. Biol. Chem. 272:7381-7389(1997).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Schneider K.,et al.EMBO Rep. 13:1138-1144(2012).
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