|Other Accession||NM_153423, NP_700472|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||AW742646, D4Ertd13e, WAVE2|
|Other Names||Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2, Protein WAVE-2, Wasf2, Wave2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Wasf2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Wasf2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane|
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Sossey-Alaoui K.,et al.Mamm. Genome 14:314-322(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Steffen A.,et al.EMBO J. 23:749-759(2004).
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