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Alpha Fodrin Antibody

Rabbit Monoclonal Antibody

  • WB - Alpha Fodrin Antibody AJ1025a
    A. Western blot analysis on (A) HeLa treated with Camptothecin, (B) HeLa, (C) Jurkat treated with Staurosporine and (D) Jurkat cell lysates using anti-alpha Fodrin RabMAb (Cat. #AJ1025a), dilution 1:1000.
  • WB - Alpha Fodrin Antibody AJ1025a
    B. Western blot analysis on (A) TF-1, (B) SH-SY5Y, (C) HeLa and (D) human brain lysates using anti-alpha Fodrin RabMAb (Cat. #AJ1025a), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13813
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3017
Calculated MW 284539 Da
Gene ID 6709
Other Names Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit, SPTAN1, NEAS, SPTA2
Target/Specificity A synthetic peptide corresponding to residues in human Alpha Fodrin was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAlpha Fodrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NEAS, SPTA2
Function Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Research Areas
Citations (0)

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Alpha Fodrin is a member of the spectrin family of widely distributed filamentous proteins that form a supporting and organizing scaffold for cell membranes (1). Non-erythroid alpha spectrin, also called Alpha Fodrin, is a major cortical cytoskeletal protein that has been implicated in the establishment of specialized membrane- cytoskeletal domains in differentiating cells (2-3). Cleavage of Alpha Fodrin accompanies apoptosis, induced by activation via the CD3/T cell receptor complex, ligation of the Fas (CD95) molecule and other Fas-expressing cells, or treatment of cells with staurosporine, dexamethasone, or synthetic ceramide (4). The major products of the cleavage are amino-terminal (135 kDa) and carboxy-terminal (150 kDa and 120 kDa) fragments. Antibodies against Alpha Fodrin are observed in diseases characterized by chronic apoptosis, and are valuable in the evaluation fo Sicca- and Sj鰃ren's syndrome (5-6).


1. Leto TL, et al. Mol Cell Biol. 8(1):1-9, 1988
2. Simonovic M, et al. J Biol Chem. 281(45):34333-40, 2006
3. DH Giebelhaus, et al. The Journal of Cell Biology 105:843-853,1987
4. Martin SJ, et al. J Biol Chem. 270(12):6425-8, 1995
5. Ulbricht K U, et al. Autoimmunity Reviews 2(2):109-113,2003
6. Kahaly, G. J., et al. Clinical & Experimental Immunology 140:166-172(7), 2005

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Cat# AJ1025a
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