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Angeiotensin Receptor-Type II Antibody

Rabbit Monoclonal IgG

  • WB - Angeiotensin Receptor-Type II Antibody AJ1044a
    Western blot analysis on (A) HepG2, (B) 293T, (C) HeLa and (D) fetal liver lysates using anti-Type-2 Angiotensin II receptor RabMAb (Cat. #AJ1044a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50052
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3876
Calculated MW 41184 Da
Gene ID 186
Other Names Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2, AGTR2
Target/Specificity A synthetic peptide corresponding to residues at the C-term of human Type-2 angiotensin II receptor was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAngeiotensin Receptor-Type II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGTR2
Function Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine
Research Areas
Citations (0)

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The angiotensin II type 2 (AT2) receptor, belonging to the seven transmembrane receptor superfamily, interacts with effector peptide angiotensin II and has demonstrated counterregulatory interactions with angiotensin II type 1 (AT1) receptor in both the cardiovascular and renal systems(1,2). Participation of AT1 and AT2 receptors in regulating blood pressure, cardiovascular growth, fibrosis, and remodeling and renal blood flow, growth, fibrosis, and sodium excretion has been suggested(3). AT2 receptor activation also suppresses renin biosynthesis and release at renal juxtaglomerular cells. (3) Unlike AT1 receptor which is expressed ubiquitously and abundantly in adult tissues, AT2 receptor expression is high in the fetus but low in adult tissues, and its cardiovascular expression increases in response to injury and AT1 receptor blocker therapy(2).


1. Porrello et al. Front Biosci. 14:958-72, 2009. 2. Schulman et al. Curr Hypertens Rep. 10(3): 188-93, 2008. 3. Carey et al. Trends Endocrinol Metab. 19(3):84-7, 2008.

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Cat# AJ1044a
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